Aaron Straight

PhD in Biochemistry (University of California San Francisco)

We study the biology of chromosomes broadly defined. Our work focuses on understanding the genetic and epigenetic control of chromosome organization and function. We use a combination of cell biology, biochemistry, microscopy, computation, and functional genomics in our laboratory to address questions in chromosome biology. Specifically, we are interested in the assembly and function of the centromere and kinetochore, RNA dependent regulation of chromatin epigenetic states, the function of repetitive elements in genomes and the physical organization of chromosomes.

Current Lab Members

Rae Brown

Rae Brown

PhD Student Straight Lab
Kelsey Fryer

Kelsey Fryer

PhD Student Straight Lab
Pragya Sidhwani

Pragya Sidhwani

Postdocs and Scientists Straight Lab
Eline Hendrix

Eline Hendrix

Postdocs and Scientists Straight Lab
Jacob Schwartz

Jacob Schwartz

Straight Lab
Nancy Paniagua

Nancy Paniagua

Postdocs and Scientists Straight Lab
Alex Leffell

Alex Leffell

Postdocs and Scientists Straight Lab

James Spudich

PhD in Biochemistry (Stanford University)

Over the last several decades the Spudich laboratory studied the structure and function of the myosin family of molecular motors in vitro and in vivo, and we developed multiple new tools, including in vitro motility assays taken to the single molecule level using laser traps. That work led us to our current focus on the human cardiac sarcomere and the molecular basis of hypertrophic and dilated cardiomyopathy. We postulated in 2015 that a majority of hypertrophic cardiomyopathy mutations are likely to be shifting b-cardiac myosin heads from a sequestered off-state to an active on-state for interaction with actin, resulting in the hypercontractility seen clinically in hypertrophic cardiomyopathy patients. This hypothesis is different from earlier prevailing views, and this viewing an old disease in a new light is the basis of our current research.

Current Lab Members

Rama Goluguri

Rama Goluguri

Postdocs and Scientists Spudich Lab
Masataka Kawana

Masataka Kawana

Spudich Lab
Makenna Morck

Makenna Morck

Spudich Lab
Neha Nandwani

Neha Nandwani

Postdocs and Scientists Spudich Lab
Divya Pathak

Divya Pathak

Postdocs and Scientists Spudich Lab
Asmita Pawar

Asmita Pawar

Postdocs and Scientists Spudich Lab
Kathy Ruppel

Kathy Ruppel

Postdocs and Scientists Spudich Lab
James Spudich

James Spudich

Faculty Spudich Lab Faculty
Seiji Yokota

Seiji Yokota

Postdocs and Scientists Spudich Lab

Julia Salzman

PhD in Statistics (Stanford University)

The Salzman Lab is primarily a computational data science laboratory focused on studying RNA biology with a secondary focus on validation and novel experimental design to enable statistical analysis of RNA expression. The group develops new data science methods to analyze the mechanism and function gene expression and RNA splicing. They design new methodology aiming to uncover how splicing is regulated at a single cell level and is dysregulated in diseases from viral infections to cancer. The Salzman Lab has active work in the area of analysis of massive single-cell sequencing projects such as Tabula Sapiens, spatial genomics and analysis of host response to SARS-CoV-2.

Current Lab Members

Rob Bierman

Rob Bierman

PhD Student Salzman Lab
Roozbeh Dehghannasiri

Roozbeh Dehghannasiri

Salzman Lab
Caroline Horn

Caroline Horn

Salzman Lab
Elisabeth Meyer

Elisabeth Meyer

PhD Student Salzman Lab
Julia Olivieri

Julia Olivieri

Salzman Lab
Peter Wang

Peter Wang

Salzman Lab

Rajat Rohatgi

MD and PhD in Cell Biology (Harvard Medical School)

The Rohatgi Lab is working to elucidate the biochemical and cell biological principles that govern signaling pathways that sit at the intersection between developmental biology and cancer. Their toolkit combines bulk biochemical techniques, such as cell-free reconstitution, with microscopy using novel optical probes to study the dynamics of signal propagation in cells. The group strives to develop novel strategies for the manipulation of these pathways for cancer therapies and applications in regenerative medicine.

Current Lab Members

Katie Delong

Katie Delong

Rohatgi Lab
Mandi Ma

Mandi Ma

Rohatgi Lab Postdocs and Scientists
Ljiljana Milenkovic

Ljiljana Milenkovic

Rohatgi Lab
Murugesh Narayanappa

Murugesh Narayanappa

Rohatgi Lab Postdocs and Scientists
Laura Nocka

Laura Nocka

Rohatgi Lab Postdocs and Scientists
Chandni Patel

Chandni Patel

PhD Student Rohatgi Lab
Ganesh Pusapati

Ganesh Pusapati

Rohatgi Lab Postdocs and Scientists
Parijat Sarkar

Parijat Sarkar

Rohatgi Lab
Yue Sun

Yue Sun

Rohatgi Lab Postdocs and Scientists
Yuki Yoshida

Yuki Yoshida

Rohatgi Lab Postdocs and Scientists