Chromatin based epigenetic information can be stably inherited through generations yet we have a poor understanding of how that information is encoded, replicated and maintained in cells. I am using the centromere as a model for studying epigenetic inheritance to understand how chromatin distributed during DNA replication is regenerated in each cell cycle.
Graduate Student in Genetics
I’m working on understanding how noncoding RNAs regulate the organization of chromosomes. I have been examining how repeat regions of eukaryotic genomes are transcribed and how the transcripts from these domains regulate the epigenetic state of the chromatin.
Each cycle of DNA replication duplicates the genome but also distributes chromatin proteins between newly duplicated daugter DNA strands. In order to maintain epigenetic information in chromatin the cell must regenerate chromatin states in each cell cycle. I am studying the coupling between DNA replication and chromatin maintenance to understand the mechanisms of epigenetic inheritance.
Graduate Student in Chemical and Systems Biology
I am interested in understanding the balance between genetic and epigenetic influences in the regulation of genome structure and activity. I am currently studying how DNA sequence influences the formation of centromeres as well as how noncoding RNAs interact with chromosomes to regulate them.
I’m interested in understanding the biochemical mechanisms that control centromere assembly. I am using a combination of in vitro reconstitution, single molecule imaging and live cell analysis to understand how centromeric chromatin is assembled specifically at the centromere in G1.