Assistant Professor of Biochemistry and of Biomedical Data Science
Ph.D. in Statistics (Stanford University)
Our goal is to develop statistical and experimental tools to construct a high dimensional picture of gene regulation, including cis and trans control of the full repertoire of RNAs expressed by cells. Currently, we are studying the function and biogenesis of circular RNA, which we recently discovered to be a ubiquitous and uncharacterized component of eukaryotic gene expression. A second major goal is to study gene expression variation in human cancer. Using massive public datasets and primary tumors, we develop new bioinformatic and statistical tools and test models. We use the cancer genome as window into functional roles played by RNA, and are attempting to characterize potential biomarkers.