Professor of Biochemistry and, by courtesy, of Chemical Engineering and of Chemistry
Ph.D. in Biochemistry (Brandeis University)
The Herschlag group's research is aimed at understanding the chemical and physical behavior underlying biological macromolecules and systems, behaviors that define the capabilities and limitations of biology. Toward this end we use multidisciplinary approaches to understand how RNA and protein enzymes assemble active sites and achieve their enormous catalytic power and exquisite specificity; we are developing a quantitative and predictive understanding of RNA folding; and we are uncovering the rules that determine RNA/protein interactions in vitro and in vivo. Our research has broad implications for evolution and function of RNA and proteins and for how RNA/protein interactions regulate gene expression.